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KMID : 0811720010050000168
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Korean Journal of Physiology & Pharmacology
2001 Volume.5 No. 0 p.168 ~ p.0
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Effects of Intra-Articular Administration of Memantine and Ketamine on Arthritic Pain in Rat
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Zhang Guo-Hua
Min Sun-Seek
Hong Seung-Kil
Han Hee-Chul
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Abstract
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The role of excitatory amino acids in peripheral nociceptive signaling is not well established. The effects of memantine and ketamine, non-competitive NMDA receptor antagonists on acute inflammatory pain were assessed in carrageenan-induced arthritic pain model in rats. The animals were tested for weight load on the affected leg at different time points and the test was done while the animal was walking. In control group the weight load on the affected leg was significantly reduced, the weight load decreased to the minimum level at 4h after carageenan injection and gradually returned to the pre-injection level by the fifth day. Intra-articular injection of memantine(1 mg/Kg; 5 mg/Kg) before carageenan injection could prevent the reduction of weight load at 4h, and lasted at least one day. Ketamine(1 mg/Kg; 5 mg/Kg) had the same effect, and lasted at least three days. These results suggest that peripheral NMDA receptor play an important role in the induction of arthritic pain induced by carrageenan injected into the knee joint cavity and provide key for local treatment of arthritic pain in patients. The study of roles of competitive NMDA receptor and non-NMDA receptor is required.
Source: Korean J Physiol Pharmacol.2001 Dec;5(Suppl II):S95
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